Scientific Documentation

Ardu, S. et al (2018) “Protection Against Discolouration by Two Over-the Counter Desensitising

Products” Oral Health Prev Dent 16(5) 439-444

Bamidis, E. & Kunzelmann K.-H. (2017) “Evaluation of a Novel Hypersensitivity Relieve Gel Being

Applied Prior to Bleaching” BSODR, Plymouth, GB

Ceci M. et al, (2015) “Effect of Self-Assembling Peptide P11-4 on Enamel Erosion: AFM and SEM

Studies” Scanning (9999): 1-8.

Doberdoli D. et al (2020) “Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for

Treatment of Early Occlusal Caries” Sci Report https://doi:10.1038/s41598-020-60815-8

Hill R. et al (2020) “An In Vitro Comparison of A Novel Self-Assembling Peptide Matrix Gel and Selected Desensitizing Toothpastes in Reducing Fluid Flow by Dentine Tubular Occlusion” J Dent Maxillofacial Res 3 (1) 1-11

Jablonski-Momeni, A. et al. (2019) “Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions” Scientific Reports 9,

Article number: 269

Müller, P. et al. (2013) “Evaluation of a tooth gel with Curolox® Technology as part of professional tooth-cleaning, with regards to patient satisfaction and the effects of hypersensitivity” Swiss Dental Hygienists Conference 2013, Lausanne.

Saxer, U.P. et al (2014) “Efficacy of CURODONT™ D’SENZ to reduce tooth sensitivity when applied before professional dental cleaning“ Internal Report.

Schlee M., et al. (2018). “Self-Assembling Peptide Matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial” J Periodontol doi: 10.1002/JPER.17-0429.

Schnatterer M. (2018). “Clinical Benefit of a Mouthrinse for the Treatment of Dentine Hypersensitivity.” Internal Report

Soares, R. et al (2017) “Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study” J Clin Diagn Res Vol-11(4): ZC136-ZC141

Stoleriu, S. et al (2019) “ Study Regarding the Capacity of Self-assembling Peptides to Remineralize the Active and Chronic Incipient Caries Lesions” Rev Chim (Bucharest) 70(8) 3073-3076

vVardis Aletsch

Bommer, C. et al (2018) “ Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing

Tooth Whitening” J Clin Dent 2018;29:57–63

Hojabri, N. (2019) “Evaluation of the Whitening Effect of a Mixture of Self-assembling Peptide and Hydroxyapatite on Bovine Enamel”, Thesis, LMU Munich

Hojabri, N. et al (2020) “Adhesion and whitening effects of P11-4 self-assembling peptide and HAP

suspension on bovine enamel.” Clin Oral Investig https://10.1007/s00784-020-03654-1

Kunzelmann, K.-H., Lysek, D.A. (2015). “Working Mechanism of Tooth Whitening Based on Hydroxyapatite Suspended in a P11-4 Peptide Matrix.” IADR Abstract 838, Boston, USA.

Xu, X. (2015). “New Approaches to Tooth Whitening Based on Changing the Optical Properties with

Calcium Phosphate Containing Suspensions”, Thesis, LMU Munich

Focus Group (2019). “Effectiveness and Reception of a novel non-peroxide whitening product as judged by consumers”, New York & Los Angeles, INTERNAL REPORT

Rheinholz Toothbrush

Wegehaupt, F. J. (2020) : “In vitro study of the toothbrush-to-tooth contact of a manual toothbrush from Ebnat AG (P00479-391077 Swiss Shine Version 01B1)”, University of Zurich, CONFIDENTIAL REPORT.

Wegehaupt, F. J. (2020) : “In vitro study of the toothbrush-to-tooth contact of a manual toothbrush from Ebnat AG (P00479-392057 Swiss Shine Version 02B2)”, University of Zurich, CONFIDENTIAL REPORT.

Aggeli, A., M. Bell, et al. (1997). “Responsive gels formed by the spontaneous self-assembly of

peptides into polymeric beta-sheet tapes.” Nature 386(6622): 259-262.


Aggeli, A., M. Bell, et al. (2003). “pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.” J Am Chem Soc 125(32): 9619-9628.

Araujo, I.J. et al. (2019) “P11-4 self-assembly peptide induces biomineralization without cytotoxicity in MDPC-23 cell line” Pulp Biology and Regeneration Group Satellite Meeting, Portland OR, USA 23- 25 June 2019

Barbosa-Martins, L.F. et al (2018) “Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin.” Materials Sep 14;11(9): pii: E1733. doi: 10.3390/ma11091733.

Burke, J.L. (2011) “In situ engineering of skeletal tissues using self-assembled biomimetic scaffolds.” PhD Thesis, University of Leeds, Leeds Dental Institute.

Carrick, L. M. et al (2007) Effect of ionic strength on the self-assembly, morphology and gelation of

pH responsive β-sheet tape-forming peptides.” Tetrahedron, 63(31): 7457-7467.

Davies, R.P.W. et al (2014). “Novel Self-Assembling Peptides, for the Treatment of Early Caries

Lesions” Caries Res (48): (2014) 404.

Davies, R.P.W. et al (2015). “Treatment of Fabricated Caries Lesions; Self-Assembling Peptides vs.

Fluoride” Caries Res (49): 359

De Sousa, J.P. et al (2019). “The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in

Dentin.” J Dent Res https://10.1177/0022034518817351

Felton, S. (2005): “Self Assembling β-sheet Peptide Networks as Smart Scaffolds for Tissue Engineering”. PhD Thesis, University of Leeds, Leeds Dental Institute.

Firth, A., et al. (2006). “Biomimetic self-assembling peptides as injectable scaffolds for hard tissue

engineering.” Nanomed (1): (2006) 189.

Kang, J., et al. (2016). “Multi-level modelling to further understanding of micro-CT data”, Enamel9

Conference, Leeds, UK.

Kind, L. et al (2017). “Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide” J Dent Res https://DOI:10.1177/0022034517698419

Kirkham, J., A. Firth, et al. (2007). “Self-assembling peptide scaffolds promote enamel remineralisation.” J Dent Res 86(5): 426-430.

Kyle, S., A. Aggeli, et al. (2010). “Recombinant self-assembling peptides as biomaterials for tissue engineering.” Biomaterials 31(36): 9395-9405.

Kyle, S., A. Aggeli, et al. (2008). “The self-assembling peptide, P11-4 for a scaffold in regenerative medicine.” Eur Cell and Materials 16(Suppl 3): 70.

Maude, S., E. Ingham, et al. (2013). “Biomimetic self-assembling peptides as scaffolds for soft tissue engineering.” Nanomedicine (Lond) 8(5): 823-847.

Saha, S., et al. (2019). “A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study” Bone 24 (127):602-611. doi: 10.1016/j.bone.2019.06.020

De Sousa, J.P., Puppin-Rontani, R.M. et al. (2018) “The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin” J Dent Res

Wilshaw, S. P., A. Aggeli, et al. (2008). “In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications.” Eur Cell and Materials 16(Suppl 3): 97.

Dental Reviews

Acharya, G. et al (2016). “Recent Biomimetic Advances in Rebuilding Lost Enamel Structure.” J Int

Oral Health 8(4):527-535

Alkilzy, M. et al (2018). “Treatment of Carious Lesions Using Self-Assembling Peptides.” Adv Dent Res

29(1): 42-47.

Alkilzy, M. & Splieth, C.H. (2020). “Self-assembling peptides for caries prevention and treatment of

initial carious lesions, a review.” Dtsch Zahnärztl Z Int 2(1): 21-25

Amaechi, B. T. (2015). “Remineralization therapies for initial caries lesions.” Current oral Health Reports 2(2): 95-101

Amaechi, B. T. (2017). “Remineralization – the buzzword for early MI caries management.” Br Dent J

223(3): 173-182.

Bonchev, A. et al (2020). “Self-assembling Peptide P 11-4: A Biomimetic Agent for Enamel

Remineralization” Int J Pept Res Ther

Buzalaf, M. A. & Pessan, J. P. (2017). “New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization» Monogr Oral Sci 26: 88-96

Clarkson, B. H. & Exterkate, R. A. M. (2015). “Noninvasive dentistry: a dream or reality?” Caries Res

49 Suppl1: 11-17

Donovan, T. E. et al. (2014). “Annual review of selected scientific literature: report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.” J Prosthet Dent 112(5): 1038-87

Gonzalez-Cabezas, C. & Fernadez, C.E., (2018) “Recent Advances in Remineralization Therapies for Caries Lesions” Adv Dent Res 29(1) 55-59

Pandya, M. & Diekwisch, T. (2019) «Enamel biomimetics-fiction or future of dentistry” Int J Oral Sci

11(1) 8

Philip, N. (2018). “State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management.” Caries Res 53: 284-295

Pitts, N. (2013). “Summary of: Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial.“ Br Dent J 2015(4): 174-175

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